Collagen-induced Expression of Collagenase-3 (mmp-13) by Primary Chondrocytes Is Mediated by Integrin Α1 and Discoidin Domain Receptor 2: a Protein Kinase C-dependent Pathway
نویسندگان
چکیده
Department of Oral Cell Biology, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University Amsterdam, Research Institute MOVE, Amsterdam, The Netherlands. Department of Orthopaedic Surgery, VU University Medical Center, Amsterdam, The Netherlands. Stem Cell and Tissue Engineering Research Group, Medical Biology Section, University Medical Center Groningen, Groningen, The Netherlands
منابع مشابه
Collagen-induced expression of collagenase-3 by primary chondrocytes is mediated by integrin α1 and discoidin domain receptor 2: a protein kinase C-dependent pathway.
OBJECTIVES To investigate whether maintaining the chondrocyte's native pericellular matrix prevents collagen-induced up-regulation of collagenase-3 (MMP-13) and whether integrin α1 (ITGα1) and/or discoidin domain receptor 2 (DDR2) modulate MMP-13 expression and which signalling pathway plays a role in collagen-stimulated MMP-13 expression. METHODS Goat articular chondrocytes and chondrons wer...
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Collagenase-3 (matrix metalloproteinase-13, MMP-13) is a recently identified human MMP with an exceptionally wide substrate specificity and restricted tissue-specific expression. Here we show that MMP-13 expression is induced in normal human skin fibroblasts cultured within three-dimensional collagen gel resulting in production and proteolytic activation of MMP-13. Induction of MMP-13 mRNAs by ...
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